If you’ve been looking into natural treatments for under-eye circles, skin rejuvenation, and hair loss, you’ve probably come across terms like PRP, PRF, and PDGF. They all come from your own blood and are packed with healing benefits, but they’re not exactly the same. Let’s break down the differences so you know what to expect.
What is PRP?
PRP (Platelet Rich Plasma) is made from your own blood. After a quick blood draw, we spin it in a centrifuge to separate out the plasma that’s loaded with platelets and growth factors.
- How it works: PRP is a liquid, so it spreads easily under the skin or across the scalp. Once injected, it gives a quick “burst” of growth factors to stimulate collagen and encourage healing.
- What it’s used for in aesthetics:
- Hair restoration (thicker, fuller hair)
- Skin rejuvenation with microneedling with SkinPen
- Acne scars and overall glow
- How long it lasts: Results typically build over a series of treatments and are maintained with follow-up sessions every few months.
What is PRF?
PRF (Platelet Rich Fibrin) is the next generation of platelet therapy. It’s also made from your own blood, but the preparation is different. No anticoagulants are used, which allows the blood to form a soft fibrin “scaffold.”
- How it works: Instead of a fast burst like PRP, PRF releases growth factors slowly over 7–14 days. That slow release means longer-lasting effects on the skin and tissue.
- What it’s used for in aesthetics:
- Under-eye hollows and dark circles
- Fine lines and wrinkles
- Skin texture and scars
- Thickened to make natural filler (EZ Gel)
- How long it lasts: PRF treatments often last longer than PRP because of the extended release. Many patients notice gradual improvements that continue for weeks after each session.
PDGF Skin Treatment: The Newest Breakthrough in Natural Rejuvenation
If you’ve heard of PRP (Platelet-Rich Plasma) or PRF (Platelet-Rich Fibrin), you know they use your own blood to stimulate healing, collagen, and hair or skin rejuvenation. What makes those treatments powerful are the growth factors inside your platelets. One of the most important of those is PDGF, Platelet-Derived Growth Factor.
And now, with AriEssence Pure PDGF+, we can deliver this powerhouse growth factor directly in a cleaner, more concentrated way.
What is PDGF?
- PDGF is a natural protein in your body that’s released whenever you’re healing.
- It acts like a messenger, telling your skin cells to make new collagen, repair tissue, and build new blood vessels.
- Provides up to 300,000 x the amount of growth factors versus PRP, PRF, or exosomes.
- In plain terms: PDGF = your body’s own repair signal for healthier, stronger, smoother skin.
How does PDGF work in aesthetics?
- With PRP and PRF, your body’s platelets release PDGF along with other growth factors.
- But now, with pharmaceutical-grade PDGF (AriEssence Pure PDGF+), we can deliver that healing signal on its own.
- This means no blood draw, more consistency, and much higher concentration compared to traditional PRP or PRF.
Benefits of PDGF Skin Treatment
- Stimulates collagen and elastin for firmer, younger-looking skin
- Helps with fine lines, wrinkles, and skin texture
- Great for under-eye treatments, microneedling, and post-laser recovery
- Can enhance results of other procedures like fillers or RF microneedling
- Minimal downtime, some redness may occur, but recovery is quick
Why choose Pure PDGF+ at our med spa?
PRP and PRF are great options, but they depend on your own blood, which means results can vary. Pure PDGF+ gives you a standardized, pharmaceutical-grade boost of what makes those treatments effective in the first place.
It’s like getting the best part of PRP/PRF, but stronger, cleaner, and more predictable.
The bottom line
PDGF is one of the key reasons platelet treatments like PRP and PRF work so well. Now, with PDGF skin therapy at our med spa, you can get the benefits of platelet science in a powerful, consistent, and minimally invasive way.
Ready to experience the next level of natural skin rejuvenation? Book your consultation today and find out how PDGF facial treatments can be customized for you.
The Key Differences
Here’s an easy way to compare PRP, PRF, and PDGF side by side:
| Treatment | What it is | Best for | How long it works |
| PRP | Liquid plasma with concentrated platelets | Hair loss, skin glow, microneedling boost | Quick burst that needs maintenance |
| PRF | Fibrin gel that slowly releases platelets and growth factors | Under-eyes, fine lines, scars | Steady results over 1–2 weeks, fewer sessions needed |
| PDGF | A growth factor naturally inside PRP and PRF | Not injected alone, but boosts healing in both | Works as part of PRP/PRF’s effectiveness |
So Which One Should You Choose?
- PRP: Best for fuller hair restoration and as a boost with microneedling.
- PRF: Great for under-eye hollows and fine lines, since it gives a slower, longer release of growth factors to delicate skin.
- EZ Gel (Albumin-PRF): A next-gen option that acts like a natural filler. Made from your own plasma proteins, it adds gentle volume while improving skin quality — ideal for under eyes, cheeks, and subtle lift.
- PDGF (Platelet-Derived Growth Factor): Offered at our med spa as a pharmaceutical-grade treatment (AriEssence Pure PDGF+). It’s one of the most powerful platelet proteins, and here you get it in concentrated form:
- Applied topically with microneedling to drive collagen and healing deeper.
- Used post-laser or resurfacing for faster recovery and better results.
- Injectable (off-label) for direct skin rejuvenation in targeted areas.
Ready to experience the next level of natural skin rejuvenation? Book your consultation today and find out how these facial treatments can be customized for you.